and EGCG Inhibit Breast Cancer Stem Cells
Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmcy - 01/01/2015
Alternative Breast Cancer Treatments: Curcumin and EGCG Inhibit Breast Cancer Stem
A small number of breast cancer stem cells inside the tumor are capable of sustaining and driving cancer cell
formation, growth and recurrence. The cancer stem cells possess self-renewal capabilities and resist chemotherapy
and generate tumor growth and metastasis.
In a laboratory setting researchers used two breast cancer cell lines with HER2 and treated them
with curcumin with or without EGCG. The combination of curcumin and EGCG treatment reduced breast cancer cell
growth by reducing CD44 and inhibiting STAT3 phosphorylation.
Researchers state “This study suggests that curcumin and EGCG function as antitumor agents for suppressing breast
CSCs (Cancer Stem Cells).”
Curcumin is a spice that is not well absorbed. Adding BioPerine (black pepper extract) to curcumin enhances
absorption by 200 to 2,000%. Bioperine may interact with the prescription Coumadin (warfarin). Click here to learn more about curcumin and BioPerine in DIMension 3 by Xymogen.
EGCG is available in Xymogen’s Green Tea 600. Each 600 mg capsule of Green Tea 600 contains 80% polyphenols, 60%
catechins, and 30% EGCG. This is equivalent to approximately 10 cups of green tea. Click here to learn more about Xymogen Green Tea 600.
I’m available to customize recommendations for alternative breast cancer treatments. Click here to learn how to make an appointment.
Bishop Natural Cancer Reports provides information on successful alternative cancer treatment strategies based
on research from medical journals.
Anticancer Research 2015 Jan;35(1):39-46. Curcumin and Epigallocatechin Gallate Inhibit the Cancer Stem
Cell Phenotype via Down-regulation of STAT3-NFκB Signaling. Chung SS1, Vadgama JV2. Division of Cancer
Research and Training, Department of Internal Medicine, Charles R. Drew University of Medicine and
Science, Los Angeles, CA, U.S.A. Division of Cancer Research and Training, Department of Internal
Medicine, Charles R. Drew University of Medicine and Science, Los Angeles, CA, U.S.A. Jonson
Comprehensive Cancer Center, Los Angeles, CA, U.S.A. UCLA Department of Medicine, Los Angeles, CA,
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