Curcumin and Triple Negative Breast CancerCurcumin inhibits the growth and metastasis of triple negative breast cancer and enhances the effectiveness of doxorubicin (Adriamycin) chemotherapy.
I have written many articles about curcumin and alternative cancer treatment strategies. The following is a specific summary of curcumin and triple negative breast cancer alternative treatment research. Laboratory cancer cell studies demonstrate curcumin inhibits the growth of triple negative breast cancer cells.[1] [2] [3] Researchers growing cancer tumors found curcumin causes triple negative breast cancer cells to die and decreases growth and migration (metastasis). [4] Laboratory cell study of triple negative breast cancer cells found curcumin enhanced the effectiveness of doxorubicin (Adriamycin) chemotherapy treatment.[5] Curcumin shows such promise in the treatment of triple negative breast cancer treatment that researchers, universities and drug companies are developing semi-synthetic versions to be used for medical drug treatment.[6] [7] Curcumin is not well absorbed from the stomach and intestines. Combining curcumin with piperine (BioPerine) increases blood levels by 200 to 2000%.[8]
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Triple Negative Breast Cancer Curcumin References [1] Molecular Medicine Reports. 2012 Dec;6(6):1267-70. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Sun XD1, Liu XE, Huang DS. [2] Korean Journal of Physiology and Pharmacology. 2013 Aug;17(4):291-7. Mutant p53-Notch1 Signaling Axis Is Involved in Curcumin-Induced Apoptosis of Breast Cancer Cells. Bae YH1, Ryu JH, et al. [3] Molecular Medicine Reports. 2012 Dec;6(6):1267-70. Curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of EGFR expression. Sun XD1, Liu XE, Huang DS. [4] Breast Cancer (Auckl). 2009 Sep 2;3:61-75. Modulation of the BRCA1 Protein and Induction of Apoptosis in Triple Negative Breast Cancer Cell Lines by the Polyphenolic Compound Curcumin. Rowe DL1, Ozbay T, [5] Journal of Agricultural Food Chemistry. 2013 Dec 4;61(48):11817-24Curcumin suppresses doxorubicin-induced epithelial-mesenchymal transition via the inhibition of TGF-β and PI3K/AKT signaling pathways in triple-negative breast cancer cells. Chen WC1, Lai YA, et al. [6] Journal of Drug Targeting. 2013 Aug;21(7):675-83. Curcumin-derivative nanomicelles for the treatment of triple negative breast cancer. Taurin S1, Nehoff H, et al. [7] Bioorganic & Medicinal Chemistry Letters. 2010 Oct 1;20(19):5818-21. Fluorinated 2'-hydroxychalcones as garcinol analogs with enhanced antioxidant and anticancer activities. Padhye S1, Ahmad A, [8] Shoba G, Joy D, Joseph T, et al. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med. 1998 May; 64 (4):353-6. [PMID: 9619120] Return from Curcumin and Triple Negative Breast Cancer to Triple Negative Breast Cancer
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Curcumin is the major component of the spice turmeric, extracted from the root (rhizomes) of the
plant Curcuma longa.
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