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Folate Limits Glioblastoma Aggressiveness and Increases Temozolomide Sensitivity

Search Terms: Glioblastoma, Temozolomide, Folate, Folic Acid, Brain Cancer Alternative Treatments, Brain Cancer Natural Treatments

By Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy - December 3, 2009

• A laboratory brain tumor study shows natural folate supplementation limits the aggressiveness of Glioblastoma brain cancer tumors. 

Researchers added folate, a natural form of vitamin B9, to glioblastoma cancer cells grown in a laboratory. Folate supplementation enhanced DNA remethylation (repair). The folate-induced DNA methylation limits glioblastoma proliferation and increases the sensitivity to temozolomide brain cancer cell death.

Reference Source: Clin Cancer Res. 2009 May 15;15(10):3519-29. Folate supplementation limits the aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and proliferation. Hervouet E, Debien E, Campion L, Charbord J, Menanteau J, Vallette FM, Cartron PF.

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Researchers used natural folate and not synthetic folic acid. Synthetic folic acid may increase the risk of several cancers, including prostate cancer, breast cancer and colon cancer, by stimulating cell growth. Folic acid is added to most dietary supplements and most fortified food, cereal and bread products.

This is a laboratory study. Researchers have not tried supplementing folate in humans with Glioblastoma multiforme brain cancer tumors.

Natural Folate helps your body repair damaged DNA inside the cells. This helps keep cells from turning into cancer or tumor cells.

I recommend taking supplements that contain natural Folinic Acid, 5-Methyl Tetrahydrofolate or 5-Formyl Tetrahydrofolate.

Food Sources of Folate Include: beans, leafy green vegetables, citrus fruits, beets, wheat germ, and meat.

Source: http://www.NaturalCancerReports.com

Return from Folate Limits Glioblastoma Aggressiveness and Increases Temozolomide Sensitivity to 2009 Natural Cancer News.