Folate Limits Glioblastoma Aggressiveness and Increases Temozolomide
Search Terms: Glioblastoma, Temozolomide, Folate, Folic Acid, Brain Cancer Alternative Treatments, Brain Cancer
By Keith D. Bishop, Clinical Nutritionist, B.Sc. Pharmacy - December 3, 2009
A laboratory brain tumor study shows natural folate supplementation limits the
aggressiveness of Glioblastoma brain cancer tumors.
Researchers added folate, a natural form of vitamin B9,
to glioblastoma cancer cells grown in a laboratory. Folate supplementation
enhanced DNA remethylation (repair). The folate-induced DNA
methylation limits glioblastoma proliferation and increases the sensitivity to temozolomide brain cancer cell
Reference Source: Clin Cancer
Res. 2009 May 15;15(10):3519-29. Folate supplementation limits the
aggressiveness of glioma via the remethylation of DNA repeats element and genes governing apoptosis and
proliferation. Hervouet E, Debien E, Campion L, Charbord J, Menanteau J, Vallette FM, Cartron
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Researchers used natural folate and not synthetic folic acid. Synthetic folic acid
may increase the risk of several cancers, including prostate cancer, breast cancer and colon cancer, by stimulating
cell growth. Folic acid is added to most dietary supplements and most fortified food, cereal and bread
This is a laboratory study. Researchers have not tried
supplementing folate in humans with Glioblastoma multiforme brain cancer tumors.
Natural Folate helps your body repair damaged DNA inside the cells. This helps
keep cells from turning into cancer or tumor cells.
I recommend taking supplements that contain natural Folinic Acid, 5-Methyl
Tetrahydrofolate or 5-Formyl Tetrahydrofolate.
Food Sources of Folate Include: beans, leafy green vegetables,
citrus fruits, beets, wheat germ, and meat.
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