Green Tea and Oral Cancer
Green Tea and Oral Cancer - EGCG in green tea kills oral cancer cells in
Epigallocatechin-3-gallate (EGCG) is the major bioactive
component of green tea. EGCG has been shown to inhibit the proliferation of many cancers. Studies have also
shown drinking green tea can reduce the incidence of Nasopharyngeal Carcinoma (NCP).
Oral squamous cell carcinoma (OSCC) accounts form most oral cancers.
In a laboratory cancer cell study researchers treated SSC-4 human oral squamous cell carcinoma (OSCC) cells with
EGCG extract. EGCG caused the OSCC cells to die in a dose and time dependent manner. In other words the higher the
dose and the longer exposure to EGCG the better the results.The researchers stated "EGCG has an excellent
potential to become a therapeutic coumpound for patients with OSCC, by inducing tumor cell death via apoptosis and autophagy."
Another group of researchers planted OSCC cells into animals. EGCG supplements decreased the oral cancer tumor
Yet another group of researchers found treatment with EGCG from green tea inhibited the growth of NCP cells by
did not affect the growth of non-magnlignant cells. EGCG also reduced the migration and invasion of the cancer
The researchers stated "EGCG can inhibit the proliferation and invasiveness,
and induce apoptosis, of NPC cells, making it a promising agent for chemoprevention or adjuvant therapy of
These research studies used concentrated EGCG powder. You can not get eough EGCG from drinking green tea. EGCG
extract capsules are available.
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Natural Oral Cancer Treatment Stratgies.
Onco Targets and Therapy. 2015 Feb 20;8:461-70.
Epigallocatechin-3-gallate suppresses cell proliferation and promotes apoptosis and autophagy in oral
cancer SSC-4 cells.
Cancer Letters. 2015 Feb 23. Upregulation of B-cell translocation gene 2 by
epigallocatechin-3-gallate via p38 and ERK signaling blocks cell proliferation in human oral squamous cell
carcinoma cells. Lee JC, Chung LC, et al.
International Journal of Molecular Sciences.
2015 Jan 23;16(2):2530-58.
Inhibits Proliferation, Invasiveness and Tumor Growth by Up-Regulation
of Adhesion Molecules, Suppression of Gelatinases Activity, and Induction of Apoptosis in Nasopharyngeal
Carcinoma Cells. Fang CY, Wu CC, et al.
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