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Bishop, Clinical Nutritionist, B.Sc. PharmacyO<`Diet and Lifestyle Influences on Prostate Cancer LNatural Care Solution - Health Nut Rx e1Diet and Lifestyle Influences on Prostate Cancer22$4Keith D. Bishop Clinical Nutritionist B.Sc. Pharmacy?9 The following research summary is for information and education use only. The information and commentary provided are not intended to replace your doctors care. You should consult with your health care provider before making changes in your diet, lifestyle and supplement program.$Prostate Cancer: Diet and LifestyleI m providing a summary of recent research on the effects diet and lifestyle has on prostate cancer. This research information will enlighten and empower you in your quest for a healthier life. $Prostate Cancer: Diet and LifestyleYou will have the basic tools to maximize your body s ability to fight prostate cancer, all other cancers and most other causes of early death. Prostate Cancer: RisksProstate cancer does not have a single cause. Prostate cancer grows over many years before being diagnosed. Prostate cancer does have some risk factors including age, race and family history or genetics.  Prostate Cancer: RisksResearch shows many modifiable factors in our environment, diet and lifestyle influence the prevention, development, growth and death of prostate cancer cells. Our body has natural mechanisms that can assist or hinder the ability to fight cancers. C<Prostate Cancer: RisksIt s estimated that 50% of cancer is preventable. Methods Mol Biol. 2009;472:25-56 One-third of the more than 500,000 cancer deaths that occur in the United States each year can be attributed to diet and physical activity habits, including overweight and obesity, while another third is caused by exposure to tobacco products. (66%) CA Cancer J Clin 2006; 56:254-281 \2Z"ZZ#Z2"#*202C %Prostate Cancer Fruits and VegetablesIncreased intake of bell peppers and broccoli decreased the risk of prostate cancer. Fruit and other vegetables did not appear to decrease the risk of prostate cancer in this study. Prostate Cancer Prostatic Dis. 2008;11(1):61-6&//95%Prostate Cancer Fruits and VegetablesConsuming broccoli interacts with GSTM1 genotype to result in complex changes to signaling pathways associated with inflammation and carcinogenesis in the prostate. PLoS ONE. 2008 Jul 2;3(7):e2568. &"" &Prostate Cancer: Fruits and VegetablesProstate cancer rates were lowest in those men with diets rich in fruits and vegetables. Researchers recommended health practitioners apply these dietary factors to try to reduce the incidence of prostate cancer. Aust Fam Physician. 2005 Apr;34(4):265-7.0**,"3.&Prostate Cancer: Fruits and VegetablesRegular consumption of tomatoes and tomato products can be recommended for the prevention of PCA. Aktuelle Urol. 2009 Jan;40(1):37-43. Higher tomato sauce intake is fatal for prostate cancer. Int J Cancer. 2007 Oct 1;121(7):1571-8.Lc%:(c%:(>cR%4/&Prostate Cancer: Fruits and VegetablesMen with recurring cancer consumed a combined tomato-rich diet and soy protein supplements for 8 weeks. > 25 mg of lycopene/day mean soy intake was 39 g / day Serum PSA decreased for 34% (14/41) of the men. Nutr Cancer. 2008;60(2):145-54.:hg hg  $Prostate Cancer: Omega-3 Fatty AcidsOmega-3 reduce inflammation and pain EPA (eicosapentanoic acid) and DHA (docosahexanoic acid) Sources: Fish Oils ALA (alpha linolenic acid) Flax Seed, Walnuts, Canola Oil L` ` JW$Prostate Cancer: Omega-3 Fatty AcidsProtective for aggressive prostate cancer, and this effect is modified by the COX-2 SNP rs4648310. Omega-3 polyunsaturated fatty acids may impact prostate inflammation and carcinogenesis through the COX-2 (inflammation) enzymatic pathway. Clin Cancer Res. 2009 Apr 1;15(7):2559-66.&++'$Prostate Cancer: Omega-3 Fatty AcidsDietary Omega-3 fatty acids may enhance the response of prostate cancer to removal therapy and retard progression to androgen-independent growth by altering tumor fatty acid content. Am J Pathol. 2008 Jul;173(1):229-41.&%%5,$Prostate Cancer: Omega-3 Fatty AcidsvEPA and DHA intakes may reduce the risk of total and advanced prostate cancer. Am J Clin Nutr. 2004 Jul;80(1):204-16.&P'P',U6-$Prostate Cancer: Omega-3 Fatty AcidsA reduced risk of prostate cancer associated with dietary fish oils, possibly acting via inhibition of arachidonic acid-derived eicosanoid biosynthesis. Br J Cancer. 1999 Dec;81(7):1238-42&$$ 3$Prostate Cancer: Omega 6 Fatty AcidsjCause inflammation and pain Linoleic acid Corn oil Safflower oil Sunflower oil Arachidonic acid Animal FatL*% *% $Prostate Cancer: Omega 6 Fatty Acids Diets high in Omega-6 fatty acids are associated with an increased risk of bone metastasis from prostate cancers Arachidonic acid (AA) and its precursor linoleic acid can be metabolized to produce pro-inflammatory chemicals. Endocr Relat Cancer. 2008 Mar;15(1):91-100.&--, Prostate Cancer: Flax Seed Studies examining the relation between ALA and prostate cancer have produced inconsistent findings. High ALA intakes or high blood and adipose tissue concentrations of ALA may be associated with a small increased risk of prostate cancer. Am J Clin Nutr. 2009 Mar 25 0c,"Prostate Cancer: FatsThere is a positive association between palmitic acid and risk of total, localized, and low-grade prostate cancer. Palmitic acid is found in palm oil, dairy products and meat. Am J Clin Nutr. 2008 Nov;88(5):1353-63.:s=(s=(P(C:&Prostate Cancer: Fats&High serum myristic acid associated with an increased risk of prostate cancer Myristic acid is found in palm and coconut oils. Cancer Epidemiol Biomarkers Prev. 2003 Dec;12(12):1422-8. Margarine intake was positively associated with prostate cancer Cancer Causes Control. 2004 Feb;15(1):11-20.bN1:A-N1:A  -P ;0  70$Prostate Cancer: Omega-9 Fatty AcidsA low ratio of oleic-to-stearic acid associated with prostate cancer risk. (oleic acid is protective) Oleic acid is an Omega-9 Stearic Acid is a thickening agent use in food preparation and common in desserts, chocolate and candy. J Urol. 2007 Dec;178(6):2391-6 :f!f!<0 $Prostate Cancer: Omega-9 Fatty Acids"Olive oil Avocado Peanuts Almonds "Prostate Cancer: Trans Fatty AcidsBlood levels of trans-fats are associated with an increased risk of non-aggressive prostate tumors. Cancer Epidemiol Biomarkers Prev. 2008 Jan;17(1):95-101. Trans Fats: hydrogenated or partially hydrogenated fats and oils. Read your food labels.6e:Ye:Y,l  s$"Prostate Cancer: Trans Fatty AcidsA strong interaction between risk and trans-FA intake for the RNASEL QQ/RQ genotype that is present in about 35 % of the population. Nutr Res Rev. 2008 Dec;21(2):174-88.&%%, !Prostate Cancer: Oxidative Damage4MDA (malondialdehyde) levels were significantly higher in patients with prostate cancer Clin Chem Lab Med. 2006;44(2):175-9. The MDA levels were higher and the antioxidant activity and zinc levels lower in the prostate cancer groups than in the healthy control. Biol Trace Elem Res. 2004 Apr;98(1):13-19 TXZ'ZZ-ZX'-`X 0Xj0 %Prostate Cancer: MDAMDA is elevated by Low vegetable and fruit intake Elevated toxic metals and minerals Mercury, lead, cadmium, arsenic, copper, etc. MDA Oxidative Free Radical Urine Tests and Heavy Metal Urine Tests are available with out a prescription. NC.lC.l   Prostate Cancer: CopperConsistently, high levels of copper have been found in many types of human cancers, including prostate, breast, colon, and lung. Recent studies suggest that copper (removal) could be used as a novel selective target for cancer therapies. Cancer Res. 2007 Feb 15;67(4):1636-44 &''0 Prostate Cancer: Copper Copper was higher (p<0.001) in patients with prostate cancer than in controls. Clin Chem Lab Med. 2006;44(2):175-9. Copper is a co-factor essential for tumor angiogenesis (growth of new blood vessels) processes and high levels of copper have been found in many types of human cancers, including prostate, breast and brain. Front Biosci. 2005 Sep 1;10:2932-9 www.ToxicWaterSolution.com tOZ&ZZ$ZZO&$fO 0Oa0ER0iProstate Cancer: LeadFEnvironmental exposure of aging males to lead may be a risk factor for prostate cancer and/or benign prostate hyperplasia possibly through generation of reactive oxygen species and/or reducing the level of zinc which acts as a cellular growth protector. Biomed Environ Sci. 2002 Dec;15(4):298-305. www.ToxicWaterSolution.com <Z-ZZ-D 00+EProstate Cancer: Carbohydrates Tumor growth can be altered by either a vegan low-fat diet or eliminating simple carbohydrates accompanied by weight loss. Curr Opin Urol. 2009 May;19(3):263-7. Starch food intake was directly associated with prostate cancer risk. Ann Oncol. 2005 Jan;16(1):152-7.L|&G!|&G!P|c@8Prostate Cancer: CarbohydratesuIncreased risk of prostate cancer was associated with the highest servings of grains. Nutr Cancer. 2009;61(2):216-24.&V V VProstate Cancer: SoyA daily diet containing four slices of a bread rich in soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer. This work provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a reduced risk of prostate cancer development and progression. Urology. 2004 Sep;64(3):510-5 .oZ Zo Prostate Cancer: CholesterolHigh cholesterol may increase the risk of prostate cancer. Cancer Causes Control. 2008 Dec;19(10):1259-66. Men with low cholesterol had a lower risk of high-grade prostate cancer. Int J Cancer. 2008 Oct 1;123(7):1693-8. L;1I*;1I*2;e 0;Q0'Prostate Cancer: Sunshine and Vitamin DElevated PSA was associated with seasons (spring and winter) and being isolated indoors. Eur Urol. 2007 Sep;52(3):708-14. Patients diagnosed during the summer and autumn had the best prognosis. Prostate. 2007 Sep 1;67(12):1362-70.LY"H%Y"H%DYa 0Yb0'Prostate Cancer: Sunshine and Vitamin D-It is estimated that there is a 30 to 50% reduction in risk for developing colorectal, breast, and prostate cancer by either increasing vitamin D intake to least 1000 IU/d vitamin D or increasing sun exposure to raise blood levels of 25(OH)D >30 ng/ml. Clin J Am Soc Nephrol. 2008 Sep;3(5):1548-54. 6//4 0'Prostate Cancer: Sunshine and Vitamin DGeographic distribution of prostate cancer mortality is the inverse of that of UV radiation. This effect is strongest in counties north of 40 degrees N latitude, where vitamin D synthesis is limited to non-winter months. These findings add additional support for the hypothesis that vitamin D insufficiency increases risk for prostate cancer. Cancer Causes Control. 2006 Oct;17(8):1091-101. *Y1Y10Yo'Prostate Cancer: Sunshine and Vitamin DoStatistically significant correlations of effective or actual survival rates with increasing latitude were found for breast, colon, gastric, lung, ovarian, pancreatic, prostate and renal cancer, and non-Hodgkin's lymphoma. Five-year survival rates south of 50 degrees N were 20%-50% higher than those near 55 degrees N. Anticancer Res. 2006 Jul-Aug;26(4A):2605-14. *B.B.0BQ!(Prostate Cancer: Sunshine and Vitamin D RGet a Blood Test! 25 Hydroxyvitamin D3 Available through your doctor or my office.(AA' Prostate Cancer: DairySkim milk, but not other dairy foods, was associated with increased risk of advanced prostate cancer. In contrast, calcium from nondairy foods was associated with lower risk of non-advanced prostate cancer. Am J Epidemiol. 2007 Dec 1;166(11):1270-9. &,, (!Prostate Cancer: DairyiLow-fat milk is a potential risk factor for prostate cancer. Cancer Epidemiol Biomarkers Prev. 2007 May;&>,>,,E   )"Prostate Cancer: ObesityThe increase in obesity from 1980 to 2002 increased high-grade prostate cancer incidence by 15.5% and prostate cancer mortality by between 7.0% and 23.0% Cancer Epidemiol Biomarkers Prev. 2009 Mar;18(3):808-15&88,  *#Prostate Cancer: ObesityBMI (body mass index) appeared to have no prognostic value for chemotherapy failure in Dutch patients with clinically localized prostate cancer and treated with prostate removal. BJU Int. 2009 Feb 11 &+$Prostate Cancer: ObesityHigher BMI correlated strongly with black race, the presence of extra-capsular extension, and higher pathologic stage. Prostate. 2009 Apr 1;69(5):520-7.&x"x",&Prostate Cancer: ObesityWeight but not prevalent diabetes is associated with greater prostate cancer mortality in men receiving combined modality treatment for locally advanced disease. J Clin Oncol. 2008 Sep 10;26(26):4333-9.&)),.'Prostate Cancer: ObesityObese patients that receive radiation therapy have a very high failure rate. Int J Radiat Oncol Biol Phys. 2009 Mar 15;73(4):1017-22.&M9M9PM"/(Prostate Cancer: ObesitySerum PSA level is influenced by some components of the metabolic syndrome (obesity, diastolic BP, HDL, and fasting blood glucose). Urology. 2008 Oct;72(4):749-54;&!!-%Prostate Cancer: ObesityAFree BMI calculator is available at www.NaturalCareSolution.com. 0$?0)Prostate Cancer: CaloriesHigh energy intake (calories) may increase the risk of prostate (especially advanced prostate cancer). Prostate. 2009 Apr 1;69(5):520-7&g!g!1*Prostate Cancer: ExercisePhysical activity did not predict prostate cancer mortality J Phys Act Health. 2008 Nov;5(6):918-29. There was a significantly increased risk of prostate cancer in the most active men compared with the least active men. Eur J Epidemiol. 2008;23(11):739-46.L=)w%=)w%, 2+Prostate Cancer: ExerciseProstate cancer survivors were more likely to be active. Cancer. 2008 Jun;112(11):2475-82. Higher vigorous physical activity level was associated with lower risk. Int J Cancer. 2007 Oct 1;121(7):1571-8.L9"I(9"I(%:2Prostate Cancer: AlcoholSlightly lower risks were observed for men who consumed 4 glasses/week. Int J Cancer. 2007 Apr 1;120(7):1529-35.&))&;3Prostate Cancer: AlcoholMen who consumed more than one drink per month had a small increased risk of prostate cancer White wine consumption was associated with increased risk Red wine, liquor, and beer were not associated with prostate cancer Nutr Cancer. 2006;56(1):50-6.&<4Prostate Cancer: AlcoholConsumption of beer or liquor is not associated with prostate cancer. There may be, however, a reduced relative risk associated with increasing level of red wine consumption. Int J Cancer. 2005 Jan 1;113(1):133-40.&((%=6Prostate Cancer: MeatJThree month randomized trial showed significant reduction in the consumption of saturated fat, animal protein, and increased consumption of vegetable proteins increased the PSA doubling time in the intervention group compared to controls. They also showed improved quality of life. Urology. 2008 Dec;72(6):1324-8. Epub 2008 Apr 8.*Z1Z1: >7Prostate Cancer: MeatzIncreased risk of prostate cancer was associated with the highest intake of meat protein. Nutr Cancer. 2009;61(2):216-24. &Z!Z!ZD=Prostate Cancer: Grilled Meat;Grilled red meat consumption was significantly associated with higher growth levels in tumor cells. (Heterocyclic amines) Grilled hamburger consumption had the highest association with growth levels. Grilled white meat had a slight increase in growth levels. Cancer Epidemiol Biomarkers Prev. 2007 Apr;16(4):803-8 >8d8<  0%A:LHealth Nut Rx  Natural Care SolutionCollonade Center 9612 N. 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    [ On-screen ShowHealth Nut RxD; @Arial Arial BlackTimes New Roman Wingdings Glass Layers2Diet and Lifestyle Influences on Prostate CancerSlide 2%Prostate Cancer: Diet and Lifestyle%Prostate Cancer: Diet and LifestyleProstate Cancer: RisksProstate Cancer: RisksProstate Cancer: Risks&Prostate Cancer Fruits and Vegetables&Prostate Cancer Fruits and Vegetables'Prostate Cancer: Fruits and Vegetables'Prostate Cancer: Fruits and Vegetables'Prostate Cancer: Fruits and Vegetables%Prostate Cancer: Omega-3 Fatty Acids%Prostate Cancer: Omega-3 Fatty Acids%Prostate Cancer: Omega-3 Fatty Acids%Prostate Cancer: Omega-3 Fatty Acids%Prostate Cancer: Omega-3 Fatty Acids%Prostate Cancer: Omega 6 Fatty Acids%Prostate Cancer: Omega 6 Fatty AcidsProstate Cancer: Flax SeedProstate Cancer: FatsProstate Cancer: Fats%Prostate Cancer: Omega-9 Fatty Acids%Prostate Cancer: Omega-9 Fatty Acids#Prostate Cancer: Trans Fatty Acids#Prostate Cancer: Trans Fatty Acids"Prostate Cancer: Oxidative DamageProstate Cancer: 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Bishop, Clinical NutritionistKeith D. Bishop, Clinical Nutritionist  !"#$%&'(*+,-./0123456789:;<=>?@ABCDEFGHIJKLMNOPQRSTUVWXYZ[\]^_`abcdefghijklmnopqrstuvwxyz{|}~     "Root EntrydO)PicturesNPCurrent UserSummaryInformation(`UPowerPoint Document()rDocumentSummaryInformation8